Tsc question of the date of Ctesibius has been much obscured of late years by those German scholars1 who assert that Ctesibius the pneumatic and hydraulic engineer mentioned by Vitruvius IX. 8. 2 is distinct and separate from Κτησίβιος Κτησίβιος μηΧανικός who is mentioned by Athenaeus Mechanicus , Philo of Byzantium , and Hedylus ap. Athenaeum Naucratitam Deipn. XI., p. 497, d-e = Anthologia Graeca ed. Cougny, Paris , 1890, Vol. III., p. 298, n. 67.

ABSTRACT:A wide range of research uses patterns of genetic variation to infer genetic similarity between individuals, typically referred to as genetic ancestry. This research includes inference of human demographic history, understanding the genetic architecture of traits, and predicting disease risk. Researchers are not just structuring an intellectual inquiry when using genetic ancestry, they are also creating analytical frameworks with broader societal ramifications. This essay presents an ethics framework in the spirit of virtue ethics for these researchers: rather than focus on (...) rule following, the framework is designed to build researchers’ capacities to react to the ethical dimensions of their work. The authors identify one overarching principle of intellectual freedom and responsibility, noting that freedom in all its guises comes with responsibility, and they identify and define four principles that collectively uphold researchers’ intellectual responsibility: truthfulness, justice and fairness, anti-racism, and public beneficence. Researchers should bring their practices into alignment with these principles, and to aid this, the authors name three common ways research practices infringe these principles, suggest a step-by-step process for aligning research choices with the principles, provide rules of thumb for achieving alignment, and give a worked case. The essay concludes by identifying support needed by researchers to act in accord with the proposed framework. (shrink)

Hypocretin regulates brain reward function and cocaine consumption in rats. The hypocretinergic (Hcrt) system is implicated in energy homeostasis, feeding and sleep regulation. Hypocretinergic cell bodies are located in the lateral hypothalamus (LH) and project throughout the brain. The aim of the present studies was to investigate the role of the Hcrt system in regulating brain reward function and the reinforcing properties of cocaine in rats. Intracranial self-stimulation (ICSS) thresholds provide an accurate measure of brain reward function in rats. Here (...) we show that a single injection of Hcrt-1 (5 µg icv) induced persistent, long-lasting elevations in ICSS thresholds in drug-naïve rats. Indeed, Hrct-1 elevated ICSS thresholds for 36 h, with peak elevations between 6 and 12 hours after injection. Hrct-1-induced threshold elevations were attenuated by an antibody known to neutralize the binding of hcrt-1 to its receptors. Taken together, these observations suggest that Hrct-1 negatively regulates brain reward function in rats. Because Hrct-1 negatively regulates brain reward function, we hypothesized that it may attenuate the increased brain reward function usually observed after cocaine consumption, and thereby alter cocaine self-administration behavior. A daily injection of Hrct-1 (1 µg icv), for 4 consecutive days, slightly increased cocaine self-administration (0.25 mg/infusion) in rats. Overall, these data demonstrate that Hrct-1 negatively regulates brain reward function, and as such may indirectly alter cocaine self-administration. Given the well-established role of hypocretin neurons in regulating feeding behavior and sleep, we hypothesize that hypocretinergic regulation of brain reward function may provide a mechanism by which appropriate and competing behaviors (e.g. sleep or feeding) may be engaged to maintain energy homeostasis. (shrink)

Uitvoerige historische speurtocht naar de betrekkingen van Erasmus met zijn Hollandse humanistische vrienden en zijn invloed op hun leven en werken.

We use a transmission chain method to establish how context and category salience influence the formation of novel stereotypes through cumulative cultural evolution. We created novel alien targets by combining features from three category dimensions—color, movement, and shape—thereby creating social targets that were individually unique but that also shared category membership with other aliens (e.g., two aliens might be the same color and shape but move differently). At the start of the transmission chains each alien was randomly assigned attributes that (...) described it (e.g., arrogant, caring, confident). Participants were given training on the alien‐attribute assignments and were then tested on their memory for these. The alien‐attribute assignments participants produced during test were used as the training materials for the next participant in the transmission chain. As information was repeatedly transmitted an increasingly simplified, learnable stereotype‐like structure emerged for targets who shared the same color, such that by the end of the chains targets who shared the same color were more likely to share the same attributes (a reanalysis of data from Martin et al., which we term Experiment 1). The apparent bias toward the formation of novel stereotypes around the color category dimension was also found for objects (Experiment 2). However, when the category dimension of color was made less salient, it no longer dominated the formation of novel stereotypes (Experiment 3). The current findings suggest that context and category salience influence category dimension salience, which in turn influences the cumulative cultural evolution of information. (shrink)

Sixteen articles by fifteen authors, two of which, the ones by Plantinga and Kenny, have never appeared in this form before. Three of the selections have been translated for the first time from French: those by B. A. O. Williams, E. Bréhier, and P. H. J. Hoenen. The latter two selections are the sole representatives of French Cartesian scholarship. This is unfortunate, as Descartes' positive contribution to modern philosophy is better reflected in recent phenomenological and existential philosophy. The dominant (...) tone of this volume is negative and piecemeal, though in terms of this limited approach to Cartesian studies there are many excellent essays in this volume. The balance of the contributors includes Ayer, Moore, Ryle, A. K. Stout, Malcolm, Hintikka, Gewirth, Prichard, Frankfurt, and Alston. The editor has included a very comprehensive bibliography.—E. A. R. (shrink)

Peter Abelard (1079–1142 ce) was the most wide‐ranging philosopher of the twelfth century. He quickly established himself as a leading teacher of logic in and near Paris shortly after 1100. After his affair with Heloise, and his subsequent castration, Abelard became a monk, but he returned to teaching in the Paris schools until 1140, when his work was condemned by a Church Council at Sens. His logical writings were based around discussion of the “Old Logic”: Porphyry's Isagoge, aristotle'S Categories and (...) On Interpretation and boethius'S textbook on topical inference. They comprise a freestanding Dialectica (“Logic”; probably c.1116), a set of commentaries (known as the Logica [Ingredientibus], c. 1119) and a later (c. 1125) commentary on the Isagoge (Logica Nostrorum Petititoni Sociorum or Glossulae). In a work Abelard called his Theologia, issued in three main versions (between 1120 and c.1134), he attempted a logical analysis of trinitarian relations and explored the philosophical problems surrounding God's claims to omnipotence and omniscience. The Collationes (“Debates,” also known as “Dialogue between a Christian, a Philosopher and a Jew”; probably c.1130) present a rational investigation into the nature of the highest good, in which the Christian and the Philosopher (who seems to be modeled on a philosopher of pagan antiquity) are remarkably in agreement. The unfinished Scito teipsum (“Know thyself,” also known as the “Ethics”; c.1138) analyses moral action. (shrink)

This collection includes papers by such leading thinkers as Michael Ayers, J.A. Passmore, Ian Hacking, Hide Ishiguro, G.E.M. Anscombe, David Pears, A.M. Quinton, and Richard Wollheim.

The fact that genes and environment contribute differentially to variation in human behaviors, traits and attitudes is central to the field of behavior genetics. Perceptions about these differential contributions may affect ideas about human agency. We surveyed two independent samples (N = 301 and N = 740) to assess beliefs about free will, determinism, political orientation, and the relative contribution of genes and environment to 21 human traits. We find that lay estimates of genetic influence on these traits cluster into (...) four distinct groups, which differentially predict beliefs about human agency, political orientation, and religiosity. Despite apparent ideological associations with these beliefs, the correspondence between mean lay estimates and published heritability estimates for the surveyed traits is large (r = .77). Belief in genetic determinism emerges as a modest predictor of accuracy in these lay estimates. Additionally, educated mothers with multiple children emerge as particularly accurate in their estimates of the genetic contribution to these traits. (shrink)

The essays collected together in this volume, many of them written by leading scholars in the field, explore the commonsensical fact that our presence as..

It's an achievement of the last couple of decades that people who work in linguistic semantics and people who work in the philosophy of language have arrived at a friendly, de facto agreement as to their respective job descriptions. The terms of this agreement are that the semanticists do the work and the philosophers do the worrying. The semanticists try to construct actual theories of meaning (or truth theories, or model theories, or whatever) for one or another kind of expression (...) in one or another natural language; for example, they try to figure out how the temperature could be rising compatibly with the substitutivity of identicals. The philosophers, by contrast, keep an eye on the large, foundational issues, such as: what's the relation between sense and denotation; what's the relation between thought and language; whether translation is determinate; and whether life is like a fountain. Every now and then the philosophers and the semanticists are supposed to get together and compare notes on their respective progress. Or lack thereof. (shrink)

Tejera, strongly influenced by Dewey, operates on the working hypothesis that art is both a kind of experience and a kind of making, and addresses himself to the "inextricably related" problems of the ends and the creation of art. Creativity becomes the key; man is viewed as "the creative animal," and artistic creation is seen as a sort of natural human activity, to be understood in relation to all other human activities. Most traditional problems of aesthetics are taken up at (...) some point, but it is not quite clear how all the parts fit together. The book contains forty-five prints and, considered in terms of its physical format, is something of a work of art in its own right.—A. E. J. (shrink)

Contrary to Favrholdt's opinion, a book that "contains many mistakes" may nevertheless be a good book; it may even be a masterpiece. Thus, although Favrholdt's Interpretation contains many mistakes, it is nevertheless a good book. Unlike most commentaries on the Tractatus, Favrholdt makes a concerted effort to come to grips with the work as a whole. He tries to show that the thesis of extensionality is fundamental, and that the rest of the Tractatus is a working out of the consequences (...) of that thesis. Several of his interpretations are highly questionable, and he has a tendency to give up too easily on some crucial points. But he does give us an original and highly provocative treatment.—A. E. J. (shrink)

Essays on various aspects of contemporary American philosophy by nine contemporary American philosophers. The essays vary in type, ranging from quick surveys of current positions through surveys used as foils for personal opinions and defenses of particular meta-philosophical positions to contributions to particular fields which say nothing about current trends. Presumably aimed at a continental audience, the book should prove helpful to anyone who knows nothing about contemporary American philosophy.—A. E. J.

In the 1963 Philosophical Lecture, Henriette Hertz Trust, of the British Academy, Hare defends the distinction between descriptive and evaluative meaning. He attacks descriptivists on the grounds that they confuse a logical connection between the word "good" and other words with a logical connection between the word "good" and certain things. The paper presupposes an acquaintance with the debate over descriptivism, and it is never clear precisely what view Hare is attacking.—A. E. J.

This addition to the plethora of elementary logic texts has little to recommend it. Part I, "Language and Logic," and Part III, "Deductive Logic and Science," suffer from an overly dogmatic treatment of controversial issues. Part II, "Logic in Argument," tries to do too much in too little space, and this effort at compression leads to a lack of clarity, imprecision, and, occasionally, downright falsehood. Singular statements are not symbolized by existential quantification, nor does " " ever mean "Every metal (...) is liquid". An "algebraic" method of proof is introduced, but is not adequately explained and its advantages over the other proof methods introduced, if any, are not brought out.—A. E. J. (shrink)

A very well-written introduction to formal logic. Among the more unusual features: Polish notation is used for the logic of statements, Principia notation for the logic of predicates; traditional logic is axiomatized, with conversion by limitation of A propositions, conversion of I propositions, and the Barbara syllogism serving as axioms; a strong emphasis on evaluation of arguments, with "genuineness," not merely formal validity, being the desideratum. The virtue of the book is its rigor, both logical and stylistic, but this rigor (...) may make some sections overly mystifying to the beginning student.—A. E. J. (shrink)

Building on Aristotle and Dewey, Mesthene argues that language plays the role of agent in the process of coming to know. He suggests a metaphysical hypothesis to account for the intelligibility of the world and elucidate the role of language in the knowing process. Mesthene's hypothesis is both interesting and important but stands in need, as the author admits, of a good bit of further investigation. J. H. Randall contributes a foreword to this volume.—A. E. J.

Bifurcation analysis of a real-time implementation of an ART network, which is functionally similar to the generalized localist model discussed in Page's manifesto shows that it yields a phase transition from local to distributed representation owing to continuous variation of the range of inhibitory connections. Hence there appears to be a qualitative dichotomy between local and distributed representations at the level of connectionistic networks conceived of as instances of nonlinear dynamical systems.

In this paper we raise three questions of clarification about Alfred Mele's fine recent book, Free Will and Luck. Our questions concern the following topics: (i) Mele's combination of 'luck' and 'Frankfurt-style' objections to libertarianism, (ii) Mele's stipulations about 'compatibilism' and the relation between questions about free action and questions about moral responsibility, and (iii) Mele's treatment of the Consequence Argument.

There has been longstanding interest in the consistency of decisions made by research ethics committees in the UK, but most of the evidence has come from single studies submitted to multiple committees. A systematic comparison was carried out of the decisions made on 18 purposively selected applications, each of which was reviewed independently by three different RECs in a single strategic health authority. Decisions on 11 applications were consistent, but disparities were found among RECs on decisions on seven applications. An (...) analysis of the agreement between decisions of RECs yielded an overall measure of agreement of κ = 0.286 , indicating a level of agreement that, although probably better than chance, may be described as “slight”. The small sample size limits the robustness of these findings. Further research on reasons for inconsistencies in decision making between RECs, and on the importance of such inconsistencies for a range of arguments, is needed. (shrink)

Many philosophers hold that luck excludes control-more precisely, that an event is lucky for you only if that event lies beyond your control. Call this the Lack of Control Requirement (LCR) on luck. Jennifer Lackey [2008] has recently argued that there is no such requirement on luck. Should such an argument succeed, it would (among other things) disable a main objection to the "libertarian" position in the free will debate. After clarifying the LCR, I defend it against both Lackey's argument (...) and a novel argument different in kind from Lackey's. I undermine each of these arguments by sketching a plausible error theory for its key intuition. For each argument, there's a natural reply available to its proponents. I show that these natural replies depend on certain mistaken general principles about luck. Neither Lackey's argument nor the novel argument I consider casts serious doubt on the LCR. [Word count: 147]. (shrink)

Graph polynomials are graph parameters invariant under graph isomorphisms which take values in a polynomial ring with a fixed finite number of indeterminates. We study graph polynomials from a model theoretic point of view. In this paper we distinguish between the graph theoretic (semantic) and the algebraic (syntactic) meaning of graph polynomials. Graph polynomials appear in the literature either as generating functions, as generalized chromatic polynomials, or as polynomials derived via determinants of adjacency or Laplacian matrices. We show that these (...) forms are mutually incomparable, and propose a unified framework based on definability in Second Order Logic. We show that this comprises virtually all examples of graph polynomials with a fixed finite set of indeterminates. Finally we show that the location of zeros and stability of graph polynomials is not a semantic property. The paper emphasizes a model theoretic view. It gives a unified exposition of classical results in algebraic combinatorics together with new and some of our previously obtained results scattered in the graph theoretic literature. (shrink)

The complex hexaploid wheat genome offers many challenges for genomics research. Expressed sequence tags facilitate the analysis of gene-coding regions and provide a rich source of molecular markers for mapping and comparison with model organisms. The objectives of this study were to construct a high-density EST chromosome bin map of wheat homoeologous group 2 chromosomes to determine the distribution of ESTs, construct a consensus map of group 2 ESTs, investigate synteny, examine patterns of duplication, and assess the colinearity with rice (...) of ESTs assigned to the group 2 consensus bin map. A total of 2600 loci generated from 1110 ESTs were mapped to group 2 chromosomes by Southern hybridization onto wheat aneuploid chromosome and deletion stocks. A consensus map was constructed of 552 ESTs mapping to more than one group 2 chromosome. Regions of high gene density in distal bins and low gene density in proximal bins were found. Two interstitial gene-rich islands flanked by relatively gene-poor regions on both the short and long arms and having good synteny with rice were discovered. The map locations of two ESTs indicated the possible presence of a small pericentric inversion on chromosome 2B. Wheat chromosome group 2 was shown to share syntenous blocks with rice chromosomes 4 and 7. (shrink)

This theory accords to volitions the status of basic mental actions, maintaining that these are spontaneous exercises of the will--a "two-way" power which ...